Atim FionaNdagire ReginaChloe NampimaFrank KiyinjiCatherine LwaniraRose Clarke NanyongaFaustino Orach-Meza2025-03-072025-03-072024-09-1110.14302/issn.2693-1176.ijgh-24- 5215https://dir.ciu.ac.ug/handle/123456789/1520Nkumba University, Entebbe Road, P.O Box 237, Entebbe, Uganda Clarke International University, Kawagga Close, Off Kalungi Road, Muyenya. Block 244|Plot 8244: Bukasa Kyadondo, Kampala-UgandaBackground: The understanding of older persons with non-communicable diseases (NCDs) regarding health well-being is paramount and can translate to increased self-efficiency, independence, and enhanced well-being. However, little is known about older persons' understanding of the concept of health-related quality of life (HRQoL) in Uganda. The study explored perceptions and unveiled understanding of older persons with NCDs on HRQoL in central Uganda. Methods: This exploratory qualitative study design involved 23 participants recruited from selected Primary healthcare facilities in Central Uganda. Thematic analysis using an inductive approach generated themes that informed the study's qualitative findings. Results: The study highlighted the physical domain as a key component of HRQoL, encompassing holistic well-being, lifestyle modification, and financial stability. To promote well-being and support a healthy aging journey, it is essential to adopt a person-centered approach that aligns with the perceptions of older adults on HRQoLenPerceptionsOlder personsnon-communicable diseasesHealth-related quality of life Central UgandaArticle